Research Stories
Research Stories
Sungkyunkwan University Research Team Led by Prof. Jeong Su Oh Identifies a Key Mechanism for Genome Stability in Mammal
New Insights into Efficient Chromosome Repair During Oocyte Meiosis
Integrative Biotechnology
Prof.
OH, JEONG SU
Crystal Lee
- A research team led by Professor Jeong Su Oh from the Department of Integrative Biotechnology at Sungkyunkwan University has revealed a novel mechanism critical for maintaining genome stability in mammalian oocytes.
- The team identified the novel BRCA1-PLK1-CIP2A axis, a pathway regulated by homologous recombination (HR), a pivotal DNA repair mechanism. This pathway ensures efficient repair of damaged chromosomes during oocyte meiosis, preventing chromosomal breaks and safeguarding genome integrity. This discovery underscores the importance of maintaining genome stability to enhance oocyte quality.
- “This research uncovers a new pathway for maintaining genomic stability in mammalian oocytes, with promising implications for advancing infertility treatments and germ cell research,” said Professor Oh. The team also highlighted the potential of this discovery to provide critical insights into diseases associated with oocyte health.
- The findings significantly contribute to our understanding of genome stability mechanisms in mammalian oocytes, offering potential applications in reproductive medicine and genetics.
- This study supported by the National Research Foundation of Korea was published online on December 9 in Nucleic Acids Research.
- Journal Details:
- Maintain Chromosome Integrity During Oocyte Meiosis
- Journal: Nucleic Acids Research (IF: 16.6; Top 2% in Biochemistry and Molecular Biology)
DOI: 10.1093/nar/gkae1207
Authors: Crystal Lee (First Author), Jeong Su Oh (Corresponding Author)
